Penicillins and cephalosporins.
نویسنده
چکیده
Resemblances and differences between the penicillins (I) and cephalosporins (II) are considered from a chemical and biochemical point of view.
منابع مشابه
Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children.
Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and thei...
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The structure-activity relationships within a series of penicillins and cephalosporins containing an N(4)-substituted piperazine-2,3-dione moiety in the C(6)/C(7)-beta-side chain are discussed.
متن کاملCorrelation between growth inhibition and the binding of various penicillins and cephalosporins to Staphylococcus aureus.
The concentration of penicillin (or cephalosporin) required to achieve a given rate of binding to Staphylococcus aureus H correlates well with that required for inhibition of growth. This result suggests that the irreversible binding of penicillins and cephalosporins to cells is responsible for their biological activity.
متن کاملUse of cephalosporins in patients with immediate penicillin hypersensitivity: cross-reactivity revisited.
A 10% cross-reactivity rate is commonly cited between penicillins and cephalosporins. However, this figure originated from studies in the 1960s and 1970s which included first-generation cephalosporins with similar side-chains to penicillins. Cephalosporins were frequently contaminated by trace amount of penicillins at that time. The side-chain hypothesis for beta-lactam hypersensitivity is supp...
متن کاملPenicillin-allergic patients: Use of cephalosporins, carbapenems, and monobactams
Antigenic components of penicillins — In order to understand the possible cross reactivity among penicillins, cephalosporins, carbapenems and monobactams, it is helpful to review the potential allergens in penicillins. Patients with IgE-mediated allergy to penicillins may be reactive to the beta-lactam ring structure that is common to all penicillins, or to the R-group side chains that distingu...
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ورودعنوان ژورنال:
- Pure and applied chemistry. Chimie pure et appliquee
دوره 28 4 شماره
صفحات -
تاریخ انتشار 1971